B cell- and monocyte-activating chemokine (BMAC), a novel non-ELR α-chemokine

ELR-CXC Chemokine Receptor Antagonism

Citrullination of epithelial neutrophil-activating peptide 78/CXCL5 results in conversion from a non-monocyte-recruiting chemokine to a monocyte-recruiting chemokine.

OBJECTIVE To examine whether the citrullinated chemokines epithelial neutrophil-activating peptide 78 (ENA-78)/CXCL5, macrophage inflammatory protein 1α/CCL3, and monocyte chemotactic protein 1/CCL2 are detected in the biologic fluid of patients with rheumatoid arthritis (RA), and if so, to determine the biologic activities of these chemokines. METHODS Recombinant human chemokines were citrul...

Chemokine-Mediated B Cell Trafficking

Monocyte chemotactic protein 3 is a most effective basophil- and eosinophil-activating chemokine

CC chemokines constitute a novel class of cytokines that attract and activate monocytes and lymphocytes, as well as basophil and eosinophil leukocytes, with distinct target cell profiles, and are believed to be involved in the regulation of different types of inflammation. The action of the recently identified monocyte chemotactic protein 3 (MCP-3) on human basophil and eosinophil function was ...

Chemokine-Mediated Inflammation Chemoattractant Protein-3) Antagonizes of CC Chemokine Ligand 7 (Monocyte A Non-Glycosaminoglycan-Binding Variant